Saccharoquinoline, a cytotoxic alkaloidal meroterpenoid from marine-derived bacterium Saccharomonospora sp

Citation:
Le, TC, Lee EJ, Lee J, Hong A, Yim CY, Yang I, Choi H, Chin J, Cho SJ, Ko J, Hwang H, Nam SJ, Fenical W.  2019.  Saccharoquinoline, a cytotoxic alkaloidal meroterpenoid from marine-derived bacterium Saccharomonospora sp. Marine Drugs. 17

Date Published:

2019/02

Keywords:

cytotoxicity, marine natural product, meroterpenoid, Pharmacology & Pharmacy, Saccharomonospora sp

Abstract:

A cytotoxic alkaloidal meroterpenoid, saccharoquinoline (1), has been isolated from the fermentation broth of the marine-derived bacterium Saccharomonospora sp. CNQ-490. The planar structure of 1 was elucidated by 1D, 2D NMR, and MS spectroscopic data analyzes, while the relative configuration of 1 was defined through the interpretation of NOE spectroscopic data. Saccharoquinoline (1) is composed of a drimane-type sesquiterpene unit in combination with an apparent 6,7,8-trihydroxyquinoline-2-carboxylic acid. This combination of biosynthetic pathways was observed for the first time in natural microbial products. Saccharoquinoline (1) was found to have cytotoxicity against the HCT-116 cancer cell line by inducing G1 arrest, which leads to cell growth inhibition.

Notes:

n/a

Website

DOI:

10.3390/md17020098

Scripps Publication ID:

98