Saccharomonopyrones A-C, New alpha-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp CNQ-490

Citation:
Yim, CY, Le TC, Lee TG, Yang I, Choi H, Lee J, Kang KY, Lee JS, Lim KM, Yee ST, Kang H, Nam SJ, Fenical W.  2017.  Saccharomonopyrones A-C, New alpha-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp CNQ-490. Marine Drugs. 15

Date Published:

2017/08

Keywords:

actinomycete, alpha-pyrones, COMMUNICATION, derivatives, differentiation, genus, inhibitor, marine natural products, nocardiopsis, polyketide synthase, Saccharomonospora sp., streptomyces sp, Yoshinone

Abstract:

Intensive study of the organic extract of the marine-derived bacterium Saccharomonospora sp. CNQ-490 has yielded three new ff-pyrones, saccharomonopyrones A-C (1-3). The chemical structures of these compounds were assigned from the interpretation of 1D, 2D NMR and mass spectrometry data. Saccharomonopyrone A (1) is the first ff -pyrone microbial natural product bearing the ethyl-butyl ether chain in the molecule, while saccharomonopyrones B and C possess unusual 3-methyl and a 6-alkyl side-chain within a 3,4,5,6-tetrasubstituted alpha-pyrone moiety. Saccharomonopyrone A exhibited weak antioxidant activity using a cation radical scavenging activity assay with an IC50 value of 140 mu M.

Notes:

n/a

Website

DOI:

10.3390/md15080239

Scripps Publication ID:

239