Fluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis

Citation:
Leutou, AS, Yang IH, Le TC, Hahn D, Lim KM, Nam SJ, Fenical W.  2018.  Fluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis. Journal of Antibiotics. 71:609-612.

Date Published:

2018/06

Keywords:

actinomadura, b-1, biosynthesis, Biotechnology & Applied Microbiology, immunology, influenza-a virus, microbiology, Pharmacology & Pharmacy

Abstract:

A new 14-membered macrolactam natural product, fluvirucin B6 (1), was isolated from a marine-derived actinomycete, Nocardiopsis sp. CNQ-115, via HPLC-UV guided isolation. The chemical structure of 1 was elucidated by 1D and 2D NMR spectroscopic data analysis. Compound 1 showed a weak activity against Gram-positive bacteria, whereas it was inactive against Gram-negative bacteria.

Notes:

n/a

Website

DOI:

10.1038/s41429-018-0033-3