4Z- and 4E-12-deoxydihydrokromycins, two naturally occurring kromycin aglycones of pikromycin from Streptomyces sp

Citation:
Yang, I, Yoon J, Kim D, Hahn D, Nam SJ, Fenical W.  2017.  4Z- and 4E-12-deoxydihydrokromycins, two naturally occurring kromycin aglycones of pikromycin from Streptomyces sp. Tetrahedron Letters. 58:2322-2324.

Date Published:

2017/06

Keywords:

14-Membered macrolide, derivatives, Kromycin derivative, Marine-derived Streptomyces, narbomycin, Pikromycin aglycone, sp., venezuelae, yc-17

Abstract:

HPLC-UV guided isolation for the culture broth extract of the marine-derived bacterium Streptomyces sp. has led to the two 14-membered macrolides, 4Z- (1) and 4E-12-dehydroxykromycins (2). The chemical structures of compounds 1 and 2 were elucidated by spectral data, while the absolute stereochemistry of 1 and 2 were determined by application of circular dichroism (CD) and analysis of X-ray crystallographic data. (C) 2017 Published by Elsevier Ltd.

Notes:

n/a

Website

DOI:

10.1016/j.tetlet.2017.03.088