Metalloproteins and the Pyrite-based Origin of Life: A Critical Assessment

Citation:
Rivas, M, Becerra A, Pereto J, Bada JL, Lazcano A.  2011.  Metalloproteins and the Pyrite-based Origin of Life: A Critical Assessment. Origins of Life and Evolution of Biospheres. 41:347-356.

Date Published:

Aug

Keywords:

acid, Aminoacyl-tRNA synthetases, biochemistry, carbon fixation, evolution, ferredoxin, FeS clusters, FeS protein folds, iron-sulfur cluster, metabolism, protein, Pyrite-dependent primordial autotrophy, Reverse Krebs cycle, transfer-rna-synthetase, transition-metal sulfides

Abstract:

We critically examine the proposal by W chtersh user (Prokaryotes 1: 275-283, 2006a, Philos Trans R Soc Lond B Biol Sci 361: 787-1808, 2006b) that putative transition metal binding sites in protein components of the translation machinery of hyper-thermophiles provide evidence of a direct relationship with the FeS clusters of pyrite and thus indicate an autotrophic origin of life in volcanic environments. Analysis of completely sequenced cellular genomes of Bacteria, Archaea and Eucarya does not support the suggestion by W chtersh user (Prokaryotes 1: 275-283, 2006a, Philos Trans R Soc Lond B Biol Sci 361: 787-1808, 2006b) that aminoacyl-tRNA synthetases and ribosomal proteins bear sequence signatures typical of strong covalent metal bonding whose absence in mesophilic species reveals a process of adaptation towards less extreme environments.

Notes:

n/a

Website

DOI:

10.1007/s11084-011-9238-1