The ammosamides: structures of cell cycle modulators from a marine-derived <i>Streptomyces</i> species

Citation:
Hughes, CC, MacMillan JB, Gaudencio SR, Jensen PR, Fenical W.  2009.  The ammosamides: structures of cell cycle modulators from a marine-derived Streptomyces species. Angewandte Chemie-International Edition. 48:725-727.

Keywords:

actinomycete, actinomycetes, alkaloids, bacterium, natural products, pyrroloiminoquinone, pyrroloquinoline alkaloids, quinolines, sponge batzella sp, thiolactams

Abstract:

From the ocean: Ammosamides A (1) and B (2) were isolated from a marine-derived Streptomyces species collected in the Bahamas. The structures of these chlorinated tricyclic pyrroloquinoline alkaloids were solved using X-ray crystallographic techniques. Ammosamide A (1) was shown to contain an unusual thio-γ-lactam ring. Both metabolites show specific nanomolar cytotoxicity against selected cancer cell lines.

Notes:

n/a

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DOI:

10.1002/anie.200804890