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Patel, S, Ramakrishnan L, Rahman T, Hamdoun A, Marchant JS, Taylor CW, Brailoiu E.  2011.  The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: Role for the two-pore channels. Cell Calcium. 50:157-167.   10.1016/j.ceca.2011.03.011   AbstractWebsite

Accumulating evidence suggests that the endo-lysosomal system provides a substantial store of Ca(2+) that is tapped by the Ca(2+)-mobilizing messenger, NAADP. In this article, we review evidence that NAADP-mediated Ca(2+) release from this acidic Ca(2+) store proceeds through activation of the newly described two-pore channels (TPCs). We discuss recent advances in defining the sub-cellular targeting, topology and biophysics of TPCs. We also discuss physiological roles and the evolution of this ubiquitous ion channel family. (C) 2011 Elsevier Ltd. All rights reserved.