The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: Role for the two-pore channels

Citation:
Patel, S, Ramakrishnan L, Rahman T, Hamdoun A, Marchant JS, Taylor CW, Brailoiu E.  2011.  The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: Role for the two-pore channels. Cell Calcium. 50:157-167.

Date Published:

Aug

Keywords:

Acidic calcium stores, adenine-dinucleotide phosphate, adp-ribose, Calcium, calcium-release channels, cyclic, Endosomes, inositol, ion-channel, Lysosomes, mobilizes calcium, NAADP, pancreatic-acinar-cells, ryanodine receptor, sea-urchin eggs, starfish oocytes, TPC1, TPC2, TPCN1, TPCN2, trisphosphate, Two-pore channels

Abstract:

Accumulating evidence suggests that the endo-lysosomal system provides a substantial store of Ca(2+) that is tapped by the Ca(2+)-mobilizing messenger, NAADP. In this article, we review evidence that NAADP-mediated Ca(2+) release from this acidic Ca(2+) store proceeds through activation of the newly described two-pore channels (TPCs). We discuss recent advances in defining the sub-cellular targeting, topology and biophysics of TPCs. We also discuss physiological roles and the evolution of this ubiquitous ion channel family. (C) 2011 Elsevier Ltd. All rights reserved.

Notes:

n/a

Website

DOI:

10.1016/j.ceca.2011.03.011